Screening of Reverse Transcriptase Inhibitor from Moringa oleifera Bioactive Compound through In Silico Study Againts HIV-1

Human immunodeficiency virus type 1 (HIV-1) from the retrovirus family can trigger opportunistic diseases of immune system or AIDS. In these conditions fails due to infection with bacteria, protozoa, fungi, and other viruses. HIV-1 has several enzymes consisting reverse transcriptase (RT), integrase (INT), & protease (PR), all which play an important role in replication process. Reverse plays a formation cDNA stages lysyl tRNA having binding site, RT then adds nucleotide synthesize non-coding U5 R (repeat) region viral RNA. activity crucial is very likely be target drug design. This study aims reveal molecular mechanism compounds Moringa oleifera antiviral for through bioinformatics approach. Kaempferitrin β-sitosterol are predicted agents. Both produce more negative affinity weak bond interactions. indicates stability interaction that triggers inhibitory activity.